🟢 New in Current Filing CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒

🟢 New in Current Filing Negative attention from special interest groups may impair our business. 🔒

🟢 New in Current Filing CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒

🟢 New in Current Filing The industries in which we operate are highly competitive. 🔒

🟢 New in Current Filing CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒

🟢 New in Current Filing We are involved in legal proceedings that could adversely affect our business, financial condition, and results of operations. 🔒

🔴 No Match in Current Filing Industry Risk Factors 🔒

🔴 No Match in Current Filing CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒

🔴 No Match in Current Filing Our business, results of operations, or financial condition could be adversely affected by disruptions in the global economy caused by the ongoing conflict between the Russian Federation and Ukraine. 🔒

🔴 No Match in Current Filing CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒

🔴 No Match in Current Filing Non-clinical contract research services create a risk of liability. 🔒

🔴 No Match in Current Filing CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒

🟡 Modified Any failure by us to comply with applicable regulations and related guidance could harm our reputation and operating results, and compliance with new regulations and guidance may result in additional costs. 🔒

🟡 Modified Costs increasing more rapidly than market prices in certain of our businesses could reduce profitability. 🔒

🟡 Modified CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒

🟡 Modified Our business is subject to risks relating to operating internationally, including changes in foreign currency exchange rates. 🔒

🟡 Modified Increasing focus on environmental, social and governance (ESG) matters, including climate-related issues, may impact our business, financial results or stock price. 🔒

🟡 Modified Legal and Regulatory Risk Factors 🔒

🟡 Modified We depend on the availability of, and good relations with, our team members. 🔒

🟡 Modified Upgrading and integrating our business systems could result in implementation issues and business disruptions. 🔒

🟡 Modified We have in the past experienced and in the future could experience unauthorized access into our information systems. 🔒

🟡 Modified Industry Risk Factors 🔒

🟡 Modified Our Biologics Solutions business, financial condition and results of operations may be adversely affected if the products we manufacture and/or test for our customers do not gain market acceptance. 🔒

🟡 Modified Risk Factor Summary 🔒

🟡 Modified We are required to comply with stringent, complex and evolving laws, rules, regulations and standards in many jurisdictions, as well as contractual obligations, relating to data privacy and security. Any actual or perceived failure to comply with these requirements could have a material adverse effect on our business. 🔒

🟡 Modified Changes in government regulation or in practices relating to the pharmaceutical or biotechnology industries, including potential healthcare reform, could decrease the need for the services we provide. 🔒

🟡 Modified If we are not successful in selecting and integrating the businesses and technologies we acquire or partner with, or in managing our current and future divestitures, our business may be adversely impacted. 🔒

🟡 Modified CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒

🟡 Modified Our operations might be affected by the occurrence of a natural disaster or other catastrophic event. 🔒

🟡 Modified Non-clinical contract research services create a risk of liability. 🔒

🟡 Modified Contaminations in our animal populations can damage our inventory, harm our reputation for contaminant-free production, result in decreased sales and cause us to incur additional costs. 🔒

🟡 Modified Changes in U.S. and International Tax Law, results of tax audits, or material changes in our stock price could have a material adverse impact on our effective tax rate and financial results. 🔒

🟡 Modified CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒

🟡 Modified Demand volatility and risk of credit losses from clients may adversely affect our business. 🔒

🟡 Modified CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 🔒